A recent alert issued by the Directorate of Drugs Control, Punjab, highlights serious concerns about using intravenous (IV) ceftriaxone with calcium-containing products, such as Ringer Lactate. This alert is based on reports of adverse drug reactions and underscores the risk of IV admixture incompatibility. Healthcare professionals are advised to take immediate action to ensure patient safety. Details of the Alert Issued By: Punjab Pharmacovigilance Center Key Concern Using IV ceftriaxone and calcium-containing products together can cause severe, potentially fatal complications due to precipitation in the bloodstream. This issue is particularly critical in neonates but extends to older infants and adults under specific conditions. Pharmacovigilance Center Findings The Pharmacovigilance Center in Punjab has reported numerous adverse reactions related to the combined use of IV ceftriaxone and calcium-containing products. Investigations revealed: ...
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