The practice of fasting, abstaining from some or all food and drink for a set period, has gained significant traction in recent years, fueled by claims of various health benefits. Beyond weight management, proponents suggest that fasting can enhance longevity, protect against neurodegenerative diseases, and even play a role in cancer prevention. At the heart of these potential benefits lies a fundamental cellular process known as autophagy, the body's intricate system for self-cleaning and recycling 1. This report delves into the fascinating connection between fasting and autophagy, exploring the molecular mechanisms that initiate this cellular renewal, the specific processes involved, and the compelling research linking it to various aspects of health and disease 1. The Spark of Self-Eating: How Fasting Initiates Autophagy at the Molecular Level The initiation of autophagy during fasting is a direct consequence of the cell's response to a reduction in available nutrients 2. W...
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